In patients with MI and unstable angina, serum levels of MMP2 and MMP9 (but not MMP1), TIMP1, TNFα and IL-6 were significantly elevated compared with healthy controls, suggesting that these MMPs, TIMP1 and proinflammatory cytokines could play an important role in the pathophysiology of acute coronary syndrome [109]. This evidence concerns the gene TIMP1 and myocardial infarction.