DEFB1 and Candidiasis, Invasive: Wiechula et al.[47] demonstrated that the mRNA of HBD-1 is increased in the lavage of female genital tract collected from women with candidiasis, which is in agreement with studies done with human normal vaginal epithelia co-cultured with C. albicans that induce a significant secretion of HBD-1 and HBD-2[48].