EFEMP2 and pulmonary emphysema: ARCL Type I is characterized by cutis laxa, pulmonary emphysema,umbilical and inguinal hernias and gastrointestinal and vesico-urinary tractdiverticuli, described in association with mutations of fibulin-5 [8] [GenBank:BC022280.1] and fibulin-4 [9] [GenBank:AF109121.1].