Hucthagowder et al. [9] identified a missense mutation (c.169 G > A; p.E57K)in FBLN4 in a child with multiple fractures, cutis laxa, vasculartortuosity and aneurysms, emphysema, inguinal and diaphragmatic hernia and jointlaxity. Here, EFEMP2 is linked to aneurysm.