Cardiovascularabnormalities resulting from inherited defects of many of these components are wellknown, e.g. Marfan syndrome (fibrillin-1) (MFS; MIM #154700), Williams-Beurensyndrome (elastin) (WBS; MIM#194050), vascular Ehlers-Danlos syndrome (type IIIcollagen) (vEDS; MIM # 130050), and hereditary cutis laxa syndromes (elastin andfibulin-4 and 5) (ADCL1 and ARCL1A; MIM #123700, 219100). The gene discussed is ELN; the disease is Marfan syndrome.