Further supporting mGluR1 involvement in epilepsy, the mGluR1-preferring antagonists LY367385 and AIDA, blocked spike-wave discharge (SWD) in lethargic mice (lh/lh) [384], a genetic model of absence epilepsy [385], and reduced sound-induced clonic seizures in DBA/2 mice [384]. This evidence concerns the gene GRM1 and epilepsy.