Remarkably, there is another type of 'connectivity' -from cell to cell- which is indeed impaired from the onset of the syndrome, and which must be integrated to WM abnormalities in a more omnibus model: schizophrenia is chiefly related to neurochemical abnormalities that affect cellular signaling at the synaptic level, and that are associated with some of the most robust genetic markers of hereditability, like Neurogulin-1 (NRG1). Here, NRG1 is linked to schizophrenia.