Several studies have shown many lines of evidence of neurodegeneration in MS, including the accumulation of amyloid precursor protein in neurons [11]; a reduction in the N-acetyl aspartate/creatine ratio, which reflects the degree of disability [12]; the finding of transected axons, which reflects the degree of inflammation within the active lesions [13]; damage to mitochondrial DNA and mitochondrial enzyme complexes [14]; and a reduction in axonal density in the white matter and spinal cords of MS patients [15,16]. The gene discussed is APP; the disease is myeloid sarcoma.