However, it has been demonstrated that MBL and its associated protease mannose-binding protein-associated serine protease 2 are strongly upregulated in the post-procedural urinary proteome profiles after application of CM, and that urine levels of MBL significantly increase in patients who developed CIN whereas MBL levels remain stable in non-CIN patients [17]. This evidence concerns the gene MASP2 and cervical squamous intraepithelial neoplasia.