We show here for the first time that i) in neodiagnosed, drug-naïve hypertensive individuals, neither RBP4 nor resistin are related with endothelial dysfunction; ii), vice versa, in healthy (normotensive non diabetic and non obese) individuals, even in the presence of RBP4 and resistin levels within the normal range, a strict relationship exists between these adipocytokines and endothelial function. The gene discussed is RETN; the disease is endothelial dysfunction.