Circulating levels of RBP4 are inversely related with brachial artery flow-mediated dilation (FMD) in type 2 diabetic individuals[11], and RBP4 levels are also increased in other clinical conditions characterized by increased cardiovascular risk and a certain degree of insulin resistance, such as essential hypertension[12] and metabolic syndrome[13]. The gene discussed is RBP4; the disease is hypertensive disorder.