The TLR4 expression levels were found to be significantly higher in HCC tissues with cirrhosis (P = 0.018), tumor size (P = 0.030), margin (P = 0.019), vascular invasion (P = 0.019), portal vein thrombosis (P = 0.014), and UICC T stage (P < 0.001) (Table 1). This evidence concerns the gene TLR4 and hepatocellular carcinoma.