Interestingly, analysis of the association of TLR4 expression and the clinicopathological characteristics of 106 HCC patients reveals that TLR4 expression is significantly correlated with margin, vascular invasion, portal vein thrombosis, and so on, which are widely accepted markers for metastasis and poor prognosis of HCC [39,40]. Here, TLR4 is linked to hepatocellular carcinoma.