CXCR1 and inflammatory skin disease: MCP-1, produced by many types of cells, is a chemokine of the C-C or beta family that has been shown to induce the recruitment of monocytes for injured tissue; its excessive production by keratinocytes has been implicated in psoriasis and other inflammatory skin diseases; transgenic mice that express murine MCP-1 in the basal layer of epidermis do not, however, exhibit spontaneous cutaneous inflammation or any other discernible skin pathology, but show hypersensitivity responses to elicited inflammation in the skin by the recruitment of dendritic and Langerhans cells [11].