In addition, recent studies showed that the ratio of HMW-adn to total adiponectin (T-adn) may be as efficient as HMW-adn to evaluate the presence of insulin resistance and metabolic syndrome (MetS)[4], while the ratio of HMW-adn to T-adn (HMW-adn/T-adn) has better predictive power for the prediction of insulin resistance and MetS than plasma T-adn level alone[5]. Here, ADIPOQ is linked to Insulin resistance.