The analysis of the relationship between EGFR and a panel of relevant RCC tumour markers (see Table 1) revealed a significant correlation with receptor tyrosine kinases, such as vascular endothelial growth factor receptor 2 (Flk1) and platelet derived growth factor receptor beta (PDGFR-β), hypoxia-inducible factor 1-alpha (Hif1-α), apoptosis regulator Bcl-2 (Bcl-2), proteins related to differentiation, such as delta-like protein 3 and 4 (DLL3 and DLL4), and proteins related to fructose uptake such as facilitated fructose transporter, member 5 (Glut5). This evidence concerns the gene DLL3 and renal cell carcinoma.