Here, we analysed for the first time a possible link between fructose metabolism and cell proliferation, which is understood to be an over-expression of EGFR in RCC; we found that both proteins characterise the same histological subtype (clear cell RCC), which shows an increase in the metabolic rate by fructose intake in cells that proliferate more. The gene discussed is EGFR; the disease is renal cell carcinoma.