Currently, no apparent links appear to exist between APOE4 and malnutrition in the elderly (Matera et al., 2010); furthermore, limited studies have found associations between cognitive impairment and malnutrition or infections in the elderly, although causality remains unclear (Orsitto et al., 2009; Fagerstrom et al., 2011). The gene discussed is APOE; the disease is malnutrition.