In a more recent study [69], schizophrenic patients with the T allele for a single-nucleotide polymorphism (SNP8NRG221533) showed significantly decreased anterior cingulum FA compared with patients homozygous for the C allele and healthy controls who were T carriers, suggesting that NRG1 variation may play a role in the white matter abnormality of this brain region in patients with schizophrenia. This evidence concerns the gene NRG1 and schizophrenia.