These include Retinoic acid-induced 1 (RAI1), from chromosome 17p11.2, which has already been implicated in cognitive and behavioral insufficiencies, Bromodomain-containing protein 1 (BRD1) from chromosome 22q13, that has been linked to schizophrenia and bipolar disorder, and the LARGE gene, on chromosome 22q12.3, which has been implicated in mental retardation and schizophrenia. Here, RAI1 is linked to bipolar disorder.