RAI1 and Intellectual disability: These include Retinoic acid-induced 1 (RAI1), from chromosome 17p11.2, which has already been implicated in cognitive and behavioral insufficiencies, Bromodomain-containing protein 1 (BRD1) from chromosome 22q13, that has been linked to schizophrenia and bipolar disorder, and the LARGE gene, on chromosome 22q12.3, which has been implicated in mental retardation and schizophrenia.