In addition, insulin like growth factor has a proliferative effect on lymphoma and leukemic cells [25].The state of hyperglycemia is also known to initiate a reactive oxygen species chain reaction and to activate several proinflammatory cytokines, such as interleukin-6 and TNF-a, which have a role in NHL pathogenesis [36]. Here, IL6 is linked to non-Hodgkin lymphoma.