In an attempt to understand the role of GLP-1 in human skeletal muscle and subsequently if this is affected by hyperglycemia, human muscle satellite cells isolated from healthy individuals were differentiated in either high (22.5 mM) or normal (5 mM) glucose conditions and the effects of GLP-1 (and insulin) on glucose metabolism and insulin signaling were assessed. The gene discussed is INS; the disease is Hyperglycemia.