In this context, it is noteworthy that a small molecule CFTR modulator, VX-770, recently developed to restore Cl− channel function of mutant CFTR in patients with CF, was also shown to improve the activity of WT CFTR Cl− channels [46] and restore cigarette-smoke induced impairment of CFTR-mediated Cl− secretion, ASL homeostasis and mucus transport in cultured non-CF human bronchial epithelia in vitro[12]. This evidence concerns the gene CFTR and cystic fibrosis.