The fact that a positive neuropsychological effect was also linked to lower PrC activity is not completely surprising as increased activation of a specific brain area is not always beneficial [see for instance the unbalanced hyper-activation found in different hippocampal areas in patients affected by schizophrenia, depression or post-traumatic stress disorder (PTSD) [58] ]. This evidence concerns the gene PPRC1 and depressive symptom measurement.