In addition, direct or indirect association of these key network genes to other cancer related genes (for example, MTDH, EXT1, ANGPT1, RAD21, EDARADD, TFF3, MARK1, DROSHA, etc seen in our networks) could create a permissive context activating or deactivating various facets of breast tumorigenesis. This evidence concerns the gene ANGPT1 and cancer.