AKR1B10 and cancer: Proposed AKR1B10-mediated tumorigenic mechanisms include retinoic acid depletion and cancer cell dedifferentiation as well as chemoresistance due to metabolism of carbonyl group–bearing anticancer drugs and activating pro-carcinogens and polycyclic aromatic hydrocarbon (PAH) transdihydrodiols to biologically reactive and redox-active oquinones [27], [28], [29].