KLF4 and hepatocellular carcinoma: To ascertain whether the effect of Klf4 on HCC anchorage-independent growth, migration and invasion correlated with in vivo phenotypes, we determined the ability of MM189 PB-Klf4 and MM189 PB cells, to grow subcutaneously in immune-compromised mice as well as to colonize to lungs after tail vein injection.