Interestingly, two of those data sets showed a trend of gradual decrease of KLF4 mRNA expression with liver disease progression: Wurmbach’s data set (GSE14520) showed consistent reduction of KLF4 mRNA in samples from tissues of normal, cirrhosis, dysplasia, to HCC in a stepwise manner [32]. This evidence concerns the gene KLF4 and hepatocellular carcinoma.