Indeed, the majority of dystrophinopathy patients have arrhythmias, long QT syndrome and contractile dysfunction [7], and therefore overlap in phenotype with patients with mutations in cypher, CRYAB, Ahnak1, or Cavin-1 [17], [21], [22], [23], [44]. Here, LDB3 is linked to neuromuscular disease caused by qualitative or quantitative defects of dystrophin.