Both continuous and 4th quartile YKL-40 values were predictive of an increased risk of stroke (HRs 1.16 (95% CI, 1.01–1.33), p = 0.004, and 1.63 (95% CI, 1.23–2.16), p = 0.001) but at the same time also seemed protective against IHD in general (HRs 0.77 (95% CI, 0.65–0.91), p = 0.002, and 0.61 (95% CI, 0.44–0.85), p = 0.003) (Table 4). This evidence concerns the gene CHI3L1 and myocardial ischemia.