Although it is not clear whether the Gly16 in ADRB2 is related to obesity, polymorphism of this site was not found in the non-human hominoids; all of them had Gly16. Since the restriction site of BsrDI was not retained in the macaques, we did not analyze them. This evidence concerns the gene ADRB2 and obesity due to melanocortin 4 receptor deficiency.