PECAM1 and neoplasm: In BPR0L075 treated tumors (Figure 3C), blood vessels were found to be distributed throughout the tumor based on anti-CD31 staining at each time point with no significant change (P>0.05), but the fluorescence intensity and distribution of Hoechst perfusion marker were significantly lower, particularly at 2 and 4 hours, with only 23±4% and 46±3% of baseline values (P<0.01, Figure 3C), though with recovery at the 24 hour time point (80±10%; P>0.05).