Consolidating these evidences, HSP90 plays a strong role in fear memory by not only translocating receptors from pre to post synaptic terminals in the hippocampus or the amygdala, but also chaperoning the glucocorticoid receptor bound cortisol to facilitate the fear learning process, which when unregulated under stress results in pathological conditions like depression. This evidence concerns the gene NR3C1 and depressive disorder.