Interestingly, even though Sema3D and sema3E inhibited either proliferation or anchorage free growth of the U87MG cells in-vitro much less effectively than sema3A (Fig. 1F & 1G), they still inhibited subcutaneous tumor development as effectively as sema3A if not more effectively (Figs. 2B & 2D). This evidence concerns the gene SEMA3A and neoplasm.