Not only could Wang et al. show that the RBP HuR (human antigen R or ELAVL1, a member of the embryonic lethal abnormal vision-like familiy) formed a ribonucleoprotein (RNP) complex with p21Cip1/WAF mRNA in RKO colorectal carcinoma cells following UV-C irradiation, but also that this complex formation appeared to be critical for p21Cip1/WAF mRNA stabilization following genotoxic stress, as HuR depletion impaired p21Cip1/WAF mRNA induction after UV-C (Wang et al., 2000). The gene discussed is ELAVL1; the disease is colorectal carcinoma.