TNFSF13B and systemic lupus erythematosus: Patients with rheumatoid arthritis (Baker, 2004) and SLE (Lebien and Tedder, 2008) exhibit elevated serum levels of BAFF and mice overexpressing BAFF develop SLE-like syndrome with expanded B-cell populations, elevated levels of anti-DNA antibodies, and immune complex deposition in the kidney (Mackay et al., 1999; Khare et al., 2000).