IL6 and Gaucher disease: In addition, the pro-inflammatory milieu associated with Gaucher’s disease, and in particular the elevated levels of the pre-osteoclastogenic cytokines interleukin (IL)-1, IL-6, and tumor necrosis factor-α (TNF-α) secreted by pathological macrophages, might be another important parameter in the pathogenesis of bone disease in these patients (de Fost et al., 2008).