In addition, the pro-inflammatory milieu associated with Gaucher’s disease, and in particular the elevated levels of the pre-osteoclastogenic cytokines interleukin (IL)-1, IL-6, and tumor necrosis factor-α (TNF-α) secreted by pathological macrophages, might be another important parameter in the pathogenesis of bone disease in these patients (de Fost et al., 2008). This evidence concerns the gene TNF and Gaucher disease.