Lin et al. [158] produced inducible line of LRRK2- or αSyn A53T-transgenic mice with a tet-off system and CaMKIIα promoter, in which the PD-related transgene can be expressed at high-level (LRRK2: about 8- to 16-fold; and αSyn A53T: about 30-fold) in neuronal cells in the striatum and cortex. This evidence concerns the gene LRRK2 and Parkinson disease.