Moreover, as activation of the WNT signaling pathway and its major mediator beta-catenin is a critical event in colorectal carcinogenesis [13], and SATB1 has been shown to interact with and recruit beta-catenin to its genomic binding sites, the role of SATB1 in CRC development and progression merits further investigation. This evidence concerns the gene SATB1 and colorectal carcinoma.