The adverse prognosis for SATB1 positive/SATB2 negative tumours was confirmed in univariable Cox regression analysis (HR = 2.63; 95% CI 1.46-4.71, p = 0.001 for CSS and HR = 2.31; 95% CI 1.32-4.04, p = 0.003 for OS), remaining significant in multivariable analysis, adjusted for age, gender, TNM stage and differentiation grade (HR = 2.07; 95% CI 1.06-4.05, p = 0.034 for CSS and HR = 2.05; 95% CI 1.09-3.88, p = 0.026 for OS) (Table 2), with a significant interaction between SATB1 and SATB2 expression (pinteraction =0.011 for CSS and 0.015 for OS) (Table 2). The gene discussed is SATB1; the disease is neoplasm.