This study included 93 patients and SATB1 was found to be up-regulated in invasive cancer compared to normal rectal mucosa, but overexpression or positive staining was denoted in < 50% of the tumours, indicating that SATB1 is less abundantly expressed than SATB2 in the lower gastrointestinal tract but may play an important role in colorectal carcinogenesis [12]. The gene discussed is SATB1; the disease is neoplasm.