However, regarding the reported Wnt pathway activation in CML cancer stem cells[28] and the reported correlation of SFRP-1 promoter methylation and resistance to imatinib[29] the impact of hypermethylation-associated gene silencing in CML in contrast to Ph-MPN has to be further elucidated. Here, SFRP1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.