This is in contrast to the methylation frequency of SFRP genes in acute lymphatic leukemia (ALL)[22], where a more balanced methylation frequency of the four genes could be shown, but confirms findings in AML showing a preferential hypermethylation of SFRP-1 (29%) and SFRP-2 (19%). This evidence concerns the gene SFRP1 and acute myeloid leukemia.