Indeed, in addition to the disruption of PML function by PML-RARα fusion protein in APL, complete or partial loss of PML protein expression has been observed in human cancers from multiple origins, such as prostate adenocarcinoma, colon adenocarcinoma, breast carcinoma, lung carcinoma, lymphoma, CNS tumors, and germ cell tumors. This evidence concerns the gene PML and breast carcinoma.