To date, several major tumor cell surface glycoprotein selectin ligands that may fulfill the criteria of “real” selectin ligands have been identified, most prominently the specialized CD44 glycoform HCELL as an E-/L-/P-selectin ligand on colon cancer cells (Hanley et al., 2005, 2006; Burdick et al., 2006), and an E-selectin ligand on prostate and breast cancer cells (Barthel et al., 2009; manuscript in preparation). This evidence concerns the gene SELE and breast cancer.