As mentioned previously, E-selectin is constitutively expressed on bone marrow endothelium (Keelan et al., 1994; Schweitzer et al., 1996), and breast cancer cells have been shown to express E-selectin ligands on their surface (Tozeren et al., 1995; Narita et al., 1996; Zen et al., 2008; Julien et al., 2011; Shirure et al., 2011, 2012). This evidence concerns the gene SELE and breast cancer.