Until recently, the main genetic modifications discovered in ACC cases involved oncosuppressor genes, such as TP53, CDKN1C, MEN1, and CDKN2A, and oncogenes such as IGF2, RAS and CTNNB1. Currently many other genes are under investigation in order to understand their usefulness for the development of new therapeutic strategies [67, 69, 80, 81]. This evidence concerns the gene TP53 and adrenal cortex carcinoma.