The systemic administration of antisense oligonucleotides would represent an interesting approach for ACC therapy; moreover, an in vitro study demonstrated that a suicide vector, in which the herpes simplex virus thymidine kinase (HSV-TK) gene was driven by the CYP11B1 promoter with a P450scc enhancer element, was able to increase chemosensitivity in Y1 mouse adrenocortical cancer cells [57, 127]. Here, TKT is linked to adrenal cortex carcinoma.