In addition to rDCs being producers of PGE2 and IL-10, the release of these mediators by stromal cells has also been implicated in their generation, with splenic endothelial-produced IL-10 (Tang et al., 2006) and tumor stroma-derived PGE2 (Liu et al., 2009) playing a role in the induction of rDC populations. Here, IL10 is linked to neoplasm.