AGTR1 and hypertensive disorder: As described above, the up-regulation of AT1 receptor in the brain has an important role in the pathophysiology of hypertension (Sved et al., 2003; Guyenet, 2006; Dupont and Brouwers, 2010) It is interesting to note that AT1 receptor is rich in the specific brain, such as, anteroventral third ventricle, PVN of the hypothalamus, NTS and RVLM in the brainstem (Allen et al., 1999; Hu et al., 2002; McKinley et al., 2003; Reja et al., 2006).