SGCG and keloid: They showed that CM-chitosan promoted proliferation of normal skin fibroblast significantly but inhibited proliferation of keloid fibroblast, because the CM-chitosan could decrease the ratio of type I/III collagen in keloid fibroblast by suppressing the secretion of type I collagen; but CM-chitosan had no effect on the secretion of types I and III collagen in the normal skin fibroblast.