On the basis of the nature of the characteristic protein inclusions, frontotemporal lobar degeneration (FTLD) can be subdivided into the more frequent FTLD-tau and FTLD-TDP subtypes, as well as FTLD-FUS and FTLD-UPS that are less common (Mioshi et al., 2010; Goedert et al., 2012). This evidence concerns the gene MAPT and frontotemporal dementia.