MAPT and neuroblastoma: To understand which processes are disrupted by Aß42 in the presence of tau aggregates, comparative proteomics was also applied to Aß42-treated P301L tau expressing neuroblastoma cells and the amygdala of P301L tau transgenic pR5 mice stereotaxically injected with Aß42: A significant fraction of proteins altered in both systems belonged to the same functional categories, i.e., proteins involved in the stress-response associated with protein folding (David et al., 2006).