EGFR and cancer: Amongst the best described examples of oncoproteins found in the cargo of cancer-derived oncosomes are members of the ErbB/HER family of receptor tyrosine kinases (RTKs), such as activated (phosphorylated) EGFR and its constitutively active mutant EGFR variant III (EGFRvIII) (Al-Nedawi et al., 2008, 2009a, 2010).