IDH1 and central nervous system cancer: In addition to the primary and secondary pathways of GBM progression involving some of the aforementioned genetic events [e.g., EGFR amplification and IDH1 mutation, respectively (Ohgaki and Kleihues, 2009)], high grade glioma is now recognized to consist of at least four major molecular subtypes (neural, proneural, classical, and mesenchymal), which differ in their genetic and epigenetic make-up (Verhaak et al., 2010).