The hypercholesterolemia, in the Reversa mouse, can be eliminated by inducing the expression of the Mx1-Cre transgene, which inactivates the gene for microsomal triglyceride transfer protein (Mttp) that is required for the secretion of apoB-containing lipoproteins (Gordon et al., 1995; Lieu et al., 2003; Feig et al., 2011). The gene discussed is APOB; the disease is familial hypercholesterolemia.