AD is characterized by neuronal and synaptic loss associated with extracellular deposits of amyloid-β peptides in senile plaques and intraneuronal neurofibrillary tangles (NFTs) formed by hyperphosphorylated tau (a microtubule-associated protein involved in microtubule stabilization; Querfurth and LaFerla, 2010). This evidence concerns the gene MAPT and Alzheimer disease.