In this regard, superoxide dismutase 1 (SOD1), peptidyl-peptidase 6 (DPP6), inositol 1,4,5-trispohosphate receptor type 2 (ITPR2) and Tar-DNA-binding protein-43 (TARDBP, also known as TD43), fused sarcoma (FUS), vamp-associated protein B/C (VAPB) have been identified as ALS susceptibility genes. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.