TRPV1-expressing afferents also mediate a number of pathological phenomena in the LUT, including bladder pain and overactive bladder (Eid, 2011; Kissin and Szallasi, 2011); recent findings suggest that these afferents also participate in pelvic organ cross-sensitization (Asfaw et al., 2011). Here, TRPV1 is linked to overactive bladder.