Similarly, a TGFβ family member BMP4 which phosphorylates different Smad (Smad1, 5 and 8) from TGFβ (Smad2 and 3) also induces EMT in pancreatic cancer cells via the induction of MSX2 (Hamada et al., 2007; Gordon et al., 2009). The gene discussed is BMP4; the disease is familial pancreatic carcinoma.