The ob/ob mice, in which leptin is knocked out, developed less severe liver fibrosis induced by either CCl4 or thioacetamide (TAA), but when leptin levels were restored liver fibrosis was aggravated, suggesting that leptin is a potential pro-fibrogenic adipocytokine (Tsukada et al., 2006). The gene discussed is LEP; the disease is Hepatic fibrosis.