PPARG and metabolic dysfunction-associated steatohepatitis: It is known than PPARγ plays a role in the maintenance of a quiescent HSC phenotype, and that PPARγ agonists suppress the fibrogenic potential of HSCs in vitro and in vivo; specifically, pioglitazone and rosiglitazone, two kinds of PPARγ agonists, have been shown to alleviate liver inflammation and fibrosis in murine NASH models (Polyzos et al., 2010; Nakagami et al., 2012).