P2RX3 and ischemia: In addition to TRPV1, P2X3, and ASIC3, it needs to point out that other muscle afferents’ receptors including μ-opioid and thromboxane (TP) receptors are engaged in processing chronic ischemia of the hindlimb muscles (Tsuchimochi et al., 2010b; Leal et al., 2011).