BRCA2 and breast cancer: Male breast cancer (MBC) is rare, accounting for less than 1% of all breast cancers.4,5 Risk factors for primary MBC include testicular disease, benign breast conditions, age, family history, the Klinefelter syndrome, gynecomasty and non-therapeutic radiation exposure.5,6 The highest risk for primary MBC is among the carriers of mutations in the BRCA2 gene.