TTP in the group of patients with wt-KRAS and wt-BRAF tumours and in the group of patients with wt-KRAS and mt-BRAF tumours was 16 months (95% CI: 10.7- 21.2 months) and 12 months (95% CI: 4.0- 15.0 months), respectively (Figure 2). This evidence concerns the gene BRAF and neoplasm.