PRL and neoplasm: Furthermore in the RT group, strong FXYD-3 expression alone or combined with PRL was related to an unfavourable prognosis independent of both, the TNM stage and tumour differentiation, which are important prognostic factors.22 In tumours with strong FXYD-3 expression, there were less tumour necrosis and a trend of increased incidence of distant metastasis after RT.